Synthesis and Urease Inhibition Studies of Barbituric and Thiobarbituric Acid Derived Sulphonamides
Identifieur interne : 000314 ( Main/Exploration ); précédent : 000313; suivant : 000315Synthesis and Urease Inhibition Studies of Barbituric and Thiobarbituric Acid Derived Sulphonamides
Auteurs : A. Rauf [Pakistan] ; F. Ahmed [Pakistan] ; A. M. Qureshi [Pakistan] ; A. M. Aziz-Ur-Rehman [Pakistan] ; A. Khan [Pakistan] ; M. I. Qadir [Pakistan] ; M. I. Choudhary [Pakistan] ; Z. H. Chohan [Pakistan] ; M. H. Youssoufid [Maroc] ; T. Ben Haddad [Maroc]Source :
- Journal of the Chinese Chemical Society [ 0009-4536 ] ; 2011-08.
English descriptors
Abstract
Various novel barbituric and thiobarbituric acid derived sulphonamides were synthesized in excellent yield via three components single pot reaction; and these were screened for in vitro urease inhibition studies against jack bean urease. The compounds 1‐7 were found to exhibit a low to moderate activity whereas compounds 8‐14 showed a significant activity (88.3‐99.9% inhibition determined at 500 μM concentration). Structures of the synthesized compounds were confirmed by 1H‐NMR, 13C‐NMR, mass spectrometry and elemental analysis data.
Url:
DOI: 10.1002/jccs.201190017
Affiliations:
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The compounds 1‐7 were found to exhibit a low to moderate activity whereas compounds 8‐14 showed a significant activity (88.3‐99.9% inhibition determined at 500 μM concentration). Structures of the synthesized compounds were confirmed by 1H‐NMR, 13C‐NMR, mass spectrometry and elemental analysis data.</div></front></TEI><affiliations><list><country><li>Maroc</li><li>Pakistan</li></country></list><tree><country name="Pakistan"><noRegion><name sortKey="Rauf, A" sort="Rauf, A" uniqKey="Rauf A" first="A." last="Rauf">A. Rauf</name></noRegion><name sortKey="Ahmed, F" sort="Ahmed, F" uniqKey="Ahmed F" first="F." last="Ahmed">F. Ahmed</name><name sortKey="Aziz R Ehman, A M" sort="Aziz R Ehman, A M" uniqKey="Aziz R Ehman A" first="A. M." last="Aziz-Ur-Rehman">A. M. Aziz-Ur-Rehman</name><name sortKey="Chohan, Z H" sort="Chohan, Z H" uniqKey="Chohan Z" first="Z. H." last="Chohan">Z. H. Chohan</name><name sortKey="Choudhary, M I" sort="Choudhary, M I" uniqKey="Choudhary M" first="M. 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